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Jo Van Ginderachter

Prof. Dr. ir. Jo VAN GINDERACHTER

ACADEMIC STAFF
+32-2-6291979

Biography

Jo Van Ginderachter is Lab Director of the Myeloid Cell Immunology lab at VIB
(Center for Inflammation Research) and of the Cellular and Molecular Immunology lab at
Vrije Universiteit Brussel. He has a long-standing expertise in macrophage biology, tumour
immunology and applications of nanobodies. He published over 100 peer-reviewed articles and 4 book chapters on these topics. Most of the grants of the Van Ginderachter lab are dealing with the characterization of tumour-associated macrophages and dendritic cells, several of which deal with nanobody-mediated imaging or therapy.

Location

Room E8.05
Vrije Universiteit Brussel
Pleinlaan 2
1050 Brussels

Publications

Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

07/09/2022

Mucosal Immunol. 2022 Sep 7. doi: 10.1038/s41385-022-00563-2. Online ahead of print.

ABSTRACT

Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear which micro-environmental factors are responsible for monocyte...

Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues

05/08/2022

Nat Protoc. 2022 Oct;17(10):2354-2388. doi: 10.1038/s41596-022-00716-4. Epub 2022 Aug 5.

ABSTRACT

Brain-immune cross-talk and neuroinflammation critically shape brain physiology in health and disease. A detailed understanding of the brain immune landscape is essential for...

Imaging and therapeutic targeting of the tumor immune microenvironment with biologics

30/03/2022

Adv Drug Deliv Rev. 2022 May;184:114239. doi: 10.1016/j.addr.2022.114239. Epub 2022 Mar 26.

ABSTRACT

The important role of tumor microenvironmental elements in determining tumor progression and metastasis has been firmly established. In particular, the presence and activity...

Macrophages are metabolically heterogeneous within the tumor microenvironment

29/12/2021

Cell Rep. 2021 Dec 28;37(13):110171. doi: 10.1016/j.celrep.2021.110171.

ABSTRACT

Macrophages are often prominently present in the tumor microenvironment, where distinct macrophage populations can differentially affect tumor progression. Although metabolism influences macrophage...

Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha

17/12/2021

Front Immunol. 2021 Nov 30;12:777524. doi: 10.3389/fimmu.2021.777524. eCollection 2021.

ABSTRACT

Glioblastoma (GBM) is the most common malignant primary brain tumor. Glioblastomas contain a large non-cancerous stromal compartment including various populations of tumor-associated...