Publications
Loss of AID exacerbates the malignant progression of CLL
Leukemia. 2022 Oct;36(10):2430-2442. doi: 10.1038/s41375-022-01663-5. Epub 2022 Aug 30.
ABSTRACT
Activation-induced cytidine deaminase (AID) has been implicated as both a positive and a negative factor in the progression of B cell chronic lymphocytic leukemia (CLL), but the role...
The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm
Front Immunol. 2022 Apr 7;13:865395. doi: 10.3389/fimmu.2022.865395. eCollection 2022.
ABSTRACT
African trypanosomes are extracellular flagellated unicellular protozoan parasites transmitted by tsetse flies and causing Sleeping Sickness disease in humans and Nagana disease in...
Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition
PLoS Negl Trop Dis. 2021 Jul 22;15(7):e0009622. doi: 10.1371/journal.pntd.0009622. eCollection 2021 Jul.
ABSTRACT
BACKGROUND: Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by...
ILC3s control splenic cDC homeostasis via lymphotoxin signaling
J Exp Med. 2021 May 3;218(5):e20190835. doi: 10.1084/jem.20190835.
ABSTRACT
The spleen contains a myriad of conventional dendritic cell (cDC) subsets that protect against systemic pathogen dissemination by bridging antigen detection to the induction of adaptive immunity. How cDC...
USP13 controls the stability of Aurora B impacting progression through the cell cycle
Oncogene. 2020 Sep;39(37):6009-6023. doi: 10.1038/s41388-020-01396-8. Epub 2020 Aug 8.
ABSTRACT
Aurora B kinase plays essential roles in mitosis. Its protein levels increase before the onset of mitosis and sharply decrease during mitosis exit. The latter decrease is due to a...