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Carl De Trez

Prof. Dr. Carl DE TREZ

ACADEMIC STAFF
+32-2-6291975

Biography

Biography

Location

Room E8.07
Vrije Universiteit Brussel
Pleinlaan 2
1050 Brussels

Publications

Loss of AID exacerbates the malignant progression of CLL

30/08/2022

Leukemia. 2022 Oct;36(10):2430-2442. doi: 10.1038/s41375-022-01663-5. Epub 2022 Aug 30.

ABSTRACT

Activation-induced cytidine deaminase (AID) has been implicated as both a positive and a negative factor in the progression of B cell chronic lymphocytic leukemia (CLL), but the role...

The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm

25/04/2022

Front Immunol. 2022 Apr 7;13:865395. doi: 10.3389/fimmu.2022.865395. eCollection 2022.

ABSTRACT

African trypanosomes are extracellular flagellated unicellular protozoan parasites transmitted by tsetse flies and causing Sleeping Sickness disease in humans and Nagana disease in...

Miltefosine enhances infectivity of a miltefosine-resistant Leishmania infantum strain by attenuating its innate immune recognition

22/07/2021

PLoS Negl Trop Dis. 2021 Jul 22;15(7):e0009622. doi: 10.1371/journal.pntd.0009622. eCollection 2021 Jul.

ABSTRACT

BACKGROUND: Miltefosine (MIL) is currently the only oral drug available to treat visceral leishmaniasis but its use as first-line monotherapy has been compromised by...

ILC3s control splenic cDC homeostasis via lymphotoxin signaling

16/03/2021

J Exp Med. 2021 May 3;218(5):e20190835. doi: 10.1084/jem.20190835.

ABSTRACT

The spleen contains a myriad of conventional dendritic cell (cDC) subsets that protect against systemic pathogen dissemination by bridging antigen detection to the induction of adaptive immunity. How cDC...

USP13 controls the stability of Aurora B impacting progression through the cell cycle

11/08/2020

Oncogene. 2020 Sep;39(37):6009-6023. doi: 10.1038/s41388-020-01396-8. Epub 2020 Aug 8.

ABSTRACT

Aurora B kinase plays essential roles in mitosis. Its protein levels increase before the onset of mitosis and sharply decrease during mitosis exit. The latter decrease is due to a...